منابع مشابه
GenAge: a genomic and proteomic network map of human ageing.
The aim of this work was to provide an overview of the genetics of human ageing to gain novel insights about the mechanisms involved. By incorporating findings from model organisms to humans, such as mutations that either delay or accelerate ageing in mice, we constructed the gene networks previously related to ageing: namely, the network related to DNA metabolism and the network involving the ...
متن کاملThe Connectivity Map: Using Gene-Expression
, 1929 (2006); 313 Science et al. Justin Lamb Connect Small Molecules, Genes, and Disease The Connectivity Map: Using Gene-Expression Signatures to This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtaine...
متن کاملA Physical Model for DT-MRI Based Connectivity Map Computation
In this study we address the problem of extracting a robust connectivity metric for brain white matter. We defined the connectivity problem as an energy minimization task, by associating the DT-field to a physical system composed of nodes and springs, with their constants defined as a function of local structure. Using a variational approach we formulated a fast and stable map evolution, which ...
متن کاملMathematical Modelling of the MAP Kinase Pathway Using Proteomic Datasets
The advances in proteomics technologies offer an unprecedented opportunity and valuable resources to understand how living organisms execute necessary functions at systems levels. However, little work has been done up to date to utilize the highly accurate spatio-temporal dynamic proteome data generated by phosphoprotemics for mathematical modeling of complex cell signaling pathways. This work ...
متن کاملtumor markers: a proteomic approach
this article reviews the recently published data on the diagnosis of cancer with proteomics, including the major proteomics technologies and promising strategies for biomarker discovery and development. most of the tumor markers are proteins that either numerically increase in response to the alteration of cancer conditions or are produced by cancer cells. however, they are natural compounds o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Systems
سال: 2018
ISSN: 2405-4712
DOI: 10.1016/j.cels.2018.04.007